A PIONEERING University of Limerick professor of surgery whose groundbreaking research led to the reclassification of an organ has published new evidence detailing the fundamental order of the abdomen.
J Calvin Coffey, Foundation Chair of Surgery at UL’s School of Medicine, whose major discovery led to the reclassification of the mesentery as a new organ in 2016, has published new research on the makeup and structure of the abdomen.
In a research paper published in the Nature Portfolio journal Communications Biology, Professor Coffey’s team has detailed the development and structure of the mesentery. In doing this, they uncovered a new order by which all contents of the abdomen are organised or arranged – or the “fundamental order of the abdomen”.
The importance of these findings on the mesentery and the impact these have on our understanding of the abdomen have been further explained in a review article just published in the Lancet Gastroenterology and Hepatology.
“Since 2016, Kevin Byrnes, Dara Walsh and members of the team been looking at the development and structure of the mesentery,” explained Professor Coffey, who is also Head of Department of Surgery, Consultant General and Colorectal Surgeon at UL Hospitals Group.
“We showed how the mesentery is a single and continuous organ in and on which all abdominal digestive organs develop and then remain connected to throughout life.
“These findings revealed a simplicity in the abdomen that was not apparent in conventional descriptions of anatomy,” he explained.
In an international collaboration, Professor Coffey’s team used a variety of state of the art techniques to clarify how the mesentery develops and the shape it has in adults.
The conclusion of the work revealed that the organisation of the abdomen has a remarkably simple design. This design is summarised in a description called the ‘Mesenteric Model of Abdominal Anatomy’.
“The abdomen is not the dauntingly complex collection of separate organs it was previously thought to be,” said Professor Coffey.
“Instead, all digestive organs are neatly packaged and arranged by the mesentery into a single digestive engine. That simplicity lay hidden until clarification of the nature of the mesentery.”
