Murphy comes into the side on the left wing with out-half Ian Keatley and full-back Felix Jones keeping their places in the starting XV.
There are two changes in the forwards as BJ Botha and Dave Foley are drafted into the pack. It will be a a big day for Tipperary man Foley as it is his first appearance in the Heineken Cup.
Penney has gone for an international front row with props Dave Kilcoyne and South African Botha either side of Varley. The back row remains unchanged with Munster captain Peter O’Mahony, Tommy O’Donnell and James Coughlan in good form heading into tomorrow’s Kingsholm encounter.
Simon Zebo is named on the bench as he returns to the squad for the first time since cracking a bone in his foot against Edinburgh in October.
Donncha O’Callaghan and JJ Hanrahan are also amongst the replacements after their recent injury issues.
Munster: Felix Jones; Keith Earls, Casey Laulala, James Downey, Johne Murphy; Ian Keatley, Conor Murray; Dave Kilcoyne, Damien Varley, BJ Botha; Dave Foley, Paul O’Connell; Peter O’Mahony (Capt.), Tommy O’Donnell, James Coughlan. Replacements: Duncan Casey, James Cronin, Stephen Archer, Donncha O’Callaghan, CJ Stander, Duncan Williams, JJ Hanrahan, Simon Zebo.
In Munster ‘A’ news,
Munster A face Nottingham at St. Mary’s RFC tonight and one change has been made to the side announced yesterday. Darren Sweetnam replaces Andrew Conway on the wing, the decision was made as a precautionary measure by the management and medical team after Conway felt tightness in his groin after training yesterday.